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 Suggested Usage: 3 capsules daily

Thyro-Mend promotes the optimal thyroid function by maintaining the health of thyroid hormone producing tissues and by supporting the healthy function of tissues that respond to thyroid hormones in both men and women. Thyroid hormones control the metabolism of proteins, carbohydrates and fats and have a significant affect on the health of brain, bones, heart, skin, nerves, immune system and every other tissue in the human body. Normal thyroid function supports healthy mood, motivation, drive, attention and memory.      

Function

Provides bio-available iodine for thyrocytes (thyroid cells that make the hormones). Increases iodine uptake by thyrocytes through interactions with sodium-iodide-symporter (NIS) proteins on the thyrocytes. Increases T3 & T4 production and secretion from thyrocytes. Increases conversion of thyroxine (T4) to the more bioactive triiodothyronine (T3) by liver cells. Increases RXR/TR heterodimerization of thyroid receptors on target cells throughout the body. Increases binding of thyroid hormone receptors to DNA by RXR/TR heterodimers throughout the body. Increases affect of T3 on target gene expression within receptor cells throughout the body.

Active Ingredients

Sea Kelp (Ascophyllum nodosum), a dietary source of bio-available iodine, increases glutathione peroxidase activity, an antioxidant required by the thyroid to prevent peroxidative damage of thyrocytes during thyroid-hormone synthesis.

Bladderwrack (Fucus vesiculosus), a dietary source of bio-available iodine, also has mild anti-estrogen properties in both human and animal studies, suggesting that it may contribute protecting the estrogen sensitive thyroid gland.

Guggul (Commiphora mukul) supports thyroid function through increased conversion of T4 to T3 in the liver, the principle site of T3 generation. Its ability to activate multiple receptors on thyrocytes nuclear membranes, including thyroid receptors (alpha & beta), retinoic acid receptors, (which pairs with thyroid receptors), and the vitamin D receptor, plays a vital role in thyroid function. Guggul supports healthy cholesterol levels and decreases LDL oxidation.

Rosemary (Rosmarinus officinalis) provides carnosic acid, which increases the expression of vitamin D and retinoid receptors. The retinoid-X-receptors (RXR) undergo heterodimerization with thyroid hormone receptors (TR). The RXR/TR heterodimers are principle mediators of target gene regulation by T3 hormone. Other constituents of rosemary include rosmarinic acid, with significant antioxidant and anxiolytic properties, as well as carnosol, which supports healthy metalloproteinase-9 activity and healthy NF-kappaB activity and normal immune system function.

Sage (Salvia officinalis) a rich source of the antioxidant carnosic acid which, as noted, can increase T3 activity through improved RXR/TR heterodimerization. Important features of Salvia officinalis are also its memory supportive properties, including memory retention, more efficient memory retrieval and improved mood and cognitive task performance.

Ashwagandha (Withania somnifera) acts on the thyroid to raise serum levels of thyroid hormones in animal and human studies and observations. Ashwagandha has profound adaptogenic properties including neuroprotective properties.

Coleus (Coleus forskohlii) contains forskolin, an activator of the cyclic AMP-generating system in many tissues including the thyroid, and increases T3 & T4 secretion from thyrocytes in a fashion similar to TSH, though independent from TSH. Forskolin is specifically able to mimic the effect of TSH in regard to iodide uptake, organification of iodine, thyroglobulin (TG) production, promotion of T3 & T4 secretion, and increased expression of sodium/iodide symporter (NIS) proteins.

Brahmi (Bacopa monniera) increases T4 serum concentrations through a direct affect on the thyroid. Brahmi improves many of the higher order cognitive processes which are often affected by sub-optimal thyroid function, including speed of visual information processing, learning rate, memory consolidation, memory retention and retention of new information.

Hops (Humulus lupulus) can increase the uptake of iodide into the thyroid gland through interactions with sodium-iodide-symporter (NIS) proteins. Xanthohumol, a chalcone found in Humulus lupulus, plays a critical role in supporting normal blood lipid and glucose metabolism.

Signs & Symptoms of Suboptimal Thyroid Function